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Symbol Name ID |
Kras
Kirsten rat sarcoma viral oncogene homolog MGI:96680 |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased lymphocyte apoptosis |
Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Increased circulating antibody level |
Paraproteinemia |
Neutropenia |
Lymphocytosis |
Monocytosis |
Leukemia |
Acute lymphoblastic leukemia |
T-cell acute lymphoblastic leukemias |
Acute myeloid leukemia |
Juvenile myelomonocytic leukemia |
Autoimmune thrombocytopenia |
Abnormality of the lymphatic system |
Lymphadenopathy |
Follicular hyperplasia |
Abnormality of the spleen |
Splenomegaly |
Hepatosplenomegaly |
Peritoneal abscess |
Autoimmunity |
Recurrent infections |
Recurrent respiratory infections |
| Disease(s) Associated with KRAS | |||||||||||||||||||||||||
| acute lymphoblastic leukemia | |||||||||||||||||||||||||
| acute myeloid leukemia | |||||||||||||||||||||||||
| autoimmune lymphoproliferative syndrome type 4 | |||||||||||||||||||||||||
| multiple myeloma | |||||||||||||||||||||||||
| Noonan syndrome | |||||||||||||||||||||||||
| Noonan syndrome 3 | |||||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | spleen vascular congestion |
increased splenocyte proliferation |
enlarged spleen |
abnormal myelopoiesis |
myeloid hyperplasia |
increased basophil cell number |
increased eosinophil cell number |
increased neutrophil cell number |
increased granulocyte number |
decreased CD8-positive, alpha-beta T cell number |
increased regulatory T cell number |
increased monocyte cell number |
increased leukocyte cell number |
increased spleen red pulp amount |
lymphoid hyperplasia |
increased inflammatory response |
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| Availability | Mouse Genotype | ||||||||||||||||
| Krastm4.1Bbd/Krastm4.1Bbd | |||||||||||||||||
| Krastm4.1Bbd/Kras+ | |||||||||||||||||
| Krastm1.1Khai/Kras+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Scgb1a1-cre)1Kkw/? (conditional) |
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| Krastm4Tyj/Kras+ (conditional) | |||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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